We don’t always have to talk about Mormon things, so now for something completely different [1]

My grandchild is at UC Berkeley doing a dual degree in Statistics and Biology. They are taking a biology class, and the book they are using is called Most Delicious Poison, by Noah Whiteman, who happens to also be the instructor of the class. They recommended the book to me, and I just finished reading it. It is not a normal textbook, more a book for the general public, but it can get dry when he starts talking about the chemical makeup of the toxins. I still have nightmares about my organic chemistry class taken 45 years ago!

In the book Whiteman talks about nature’s toxins, why the plants have them, and how we as humans have co-opted them for our on use. There was lots of fascinating facts in the book, of which I’ll share a few.

  1. In one Neanderthal skull dating to 50,000 years ago, they found evidence via DNA of a dental abscess that was infected, causing a diarrheal disease. This probably killed the guy. But they also found in the tartar buildup behind his front teeth (he was not brushing well!) the DNA sequence from poplar trees, and the fungus Penicillium. Poplar trees are a common source of salicylic acid, which we use today to make aspirin. The Penicillium species are molds that produce the antibiotic penicillin. Nether poplar trees nor the mold provide any nutrition, so the conclusion is that this man from 50,000 years ago was medicating with aspirin and penicillin for his dental infection.
  2. There is a plant that give off a toxin called pirene when an insect is eating the leaves. This suppresses the feeding rates of the insect. More importantly, there is a wasp that when it smells the pirene, it flies to the plant knowing there will be food there, and eats the insect that is chewing on the leaves. It is a win-win for this cross species arrangement. The plant get a break from the insect eating it, and the wasp gets a meal. As an aside, pirene is the active ingredient in the sleep medication Ambien.
  3. Over 50% of the drugs we use today originated from nature. All your spices in the kitchen are toxins that plants use as poison to ward off herbivores.
  4. Citrus juice can cause third degree chemical skin burns when placed on the skin and exposed to UVA light. There is a toxin in the juice that is activated by the light and makes its way into the skin cells to bind with the DNA, which cause the cells to die. A 30 year old man was badly burned when he was squeezing limes for margaritas, then exposed himself to the sun.
  5. The monarch butterfly has a toxin in its body from the milkweed leaves it eats as a caterpillar that causes birds to vomit if eaten. The birds learn their lesson, and avoid the distinctly colored butterfly.
  6. People who drink 2.5 to 4.5 cups of coffee a day in one study were 29% less likely to die during the study. This held true even if the coffee was decaffeinated, leading researchers to believe it was the antioxidants that were helping, not the caffeine. But caffeine helps with depression. Drinking 2-3 cups of caffeinated coffee per day is associated with reducing depression 25-50% in large studies involving hundreds of thousands of people. Also drinking 2-3 cups of caffeinated coffee is associated with a staggering 45% reduced risk of suicide compared to those that don’t drink coffee. (you can take this as your Mormon connection)

All these toxins, from cinnamon and nutmeg to opium, were in the plants to help ward off enemies. They usually taste bitter, and drive away the insects. But humans and our predecessors (and other animals) have been using them for medicinal and recreational purposes for tens of thousands of years.

[1] Extra points if you got the Monty Python reference