I’m reading the 65-page chapter titled “Caffeine” in Michael Pollan’s book This Is Your Mind on Plants (Penguin Press, 2021). His books are always entertaining as well as informative. I’m just going to hit on the interesting points as I read along.

Here are the symptoms of caffeine withdrawal: “headache, fatigue, lethargy, difficulty concentrating, decreased motivation, irritability, intense distress, loss of confidence, and dysphoria” (p. 93). An opposite set of descriptions apply to the caffeinated brain and body: energy, concentration, motivation, focus, and so forth. The predictable result: “Something like 90 percent of humans ingest caffeine regularly …” (p. 92).

Plants produce caffeine, of course. They do so because it was an effective adaptation: caffeine wards off predatory insects while, in some cases, attracting pollinators (the bees like the buzz and come back for more). Given the attraction caffeine has for humans, caffeine addiction has been a boon for caffeine-producing plants, which are now widely cultivated. From the point of view of the plant species, caffeine has manipulated humans into spreading the plants widely. That’s evolutionary success.

Before the 17th century, when coffee was introduced to Europe, when the ale house and the tavern ruled town and village, alcohol was the drug of choice (which killed bacteria and was therefore a healthier beverage than water). After coffee arrived, which was boiled in preparation (also killing pathogens), the state of mind of much of the population changed. From alcohol-induced quiescence and brain fog, to caffeine-fueled energy and concentration. [Note: Coffee displacing alcohol means coffee promotes sobriety.] Suddenly everyone became more productive. Voltaire drank 70 cups a day (p. 112) and other scientists and intellectuals followed a similar regime, if not to such a degree. Supported by first-person reports of caffeine-fueled writing or research, the author suggests the discoveries of the Age of Science (17th century) and the Enlightenment (18th century) owe a debt to caffeine.

Seriously? Well, such speculation is to some degree supported by more recent studies as well. Pollan reports:

I found numerous studies conducted over the years reporting that caffeine improved performance on a range of cognitive measures — of memory, focus, alertness, vigilance, attention, and learning. An experiment done in the 1930s found that chess players on caffeine performed significantly better than players who abstained. In another study, caffeine users completed a variety of mental tasks more quickly, though they made more errors: as one paper put it, people on caffeine are faster, not smarter. (p. 117-18).

What about negative effects? Surely there must be some? Well, it affects sleep by binding to and therefore blocking neuroreceptors for adenosine, “a psychoactive compound that has a depressive and hypnotic (that is, sleep-inducing) effect on the brain when it binds to its receptor” (p. 131). Let’s not minimize the cost of less and poorer sleep. An English researcher concluded: “The shorter you sleep, the shorter your lifespan” (p. 134).

But for the most part, caffeine has been absolved of serious negative effects:

The current scientific consensus is more than reassuring — in fact, the research suggests that coffee and tea, far from being deleterious to our health, may offer some important benefits, as long as they aren’t consumed to excess. Regular coffee consumption is associated with a decreased risk of several cancers (including breast, prostate, colorectal, and endomerial), cardiovascular disease, type 2 diabetes, Parkinson’s disease, dementia, and possibly depression and suicide. (p. 133)

So much for avoiding coffee and caffeine as part of a “law of health.” Caveat: the risk of committing suicide increases among those who drink more than 7 cups of coffee per day. That would be, what, maybe 30 Diet Cokes? Coffee, even decaf, also provides antioxidants.

Here’s where we turn to readers to get some additional first-person reports. Some of you drink a couple of cups of coffee a day. Some of you drink a few Diet Cokes a day. I drink a Coke Zero mid-morning and try to stop there, generally successfully. And some of you don’t do any caffeine.

So what is your relationship with and experience of caffeine?

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